Graphics Processing Units (GPUs) represent a state-of-the-art acceleration technology for general-purpose computation. GPUs are based on many-core architecture that can deliver computing performance much higher than desktop computers based on Central Processing Units (CPUs). A typical GPU device may have hundreds or thousands of processing cores that work together for massively parallel computing. Basic hardware architecture and software standards that support the use of GPUs for general-purpose computation are illustrated by focusing on Nvidia GPUs and its software framework: CUDA. Many-core GPUs can be leveraged for the acceleration of spatial problem-solving.